What is NYVEPRIA?
NYVEPRIA is a prescription medicine that boosts white blood cells and can help reduce the risk of infection during chemotherapy. Your doctor may recommend it for your first cycle through your last.
NYVEPRIA is an FDA-approved biosimilar* to Neulasta® (pegfilgrastim). This means there are no clinically meaningful differences in terms of safety, purity, or potency (effectiveness). That is, NYVEPRIA is expected to work in the same way as Neulasta.
Possible side effects of NYVEPRIA
It is important to know the potential side effects of NYVEPRIA. Your doctor may stop treatment if any serious side effects occur. Be sure to contact your healthcare team if there are any signs of the side effects listed below.
NYVEPRIA may cause serious side effects, including:
Your spleen may become enlarged and can rupture while taking NYVEPRIA. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the upper-left stomach area or left shoulder.
A serious lung problem called acute respiratory distress syndrome (ARDS)
Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
Serious allergic reactions
NYVEPRIA can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have these symptoms, stop using NYVEPRIA and call your healthcare provider or get emergency medical help right away.
Sickle cell crises
You may have a serious sickle cell crisis, which could lead to death, if you have a sickle cell disorder and receive NYVEPRIA. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
Kidney injury (glomerulonephritis)
NYVEPRIA can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
- swelling of your face or ankles
- blood in your urine or dark-colored urine
- you urinate less than usual
Increased white blood cell count (leukocytosis)
Your healthcare provider will check your blood during treatment with NYVEPRIA.
Decreased platelet count (thrombocytopenia)
Your healthcare provider will check your blood during treatment with NYVEPRIA. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NYVEPRIA. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
Capillary Leak Syndrome
NYVEPRIA can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
- swelling or puffiness and are urinating less than usual
- trouble breathing
- swelling of your stomach area (abdomen) and feeling of fullness
- dizziness or feeling faint
- a general feeling of tiredness
Myelodysplastic syndrome and acute myeloid leukemia
If you have breast cancer or lung cancer, when NYVEPRIA is used with chemotherapy and radiation therapy, or with radiation therapy alone, you may have an increased risk of developing a precancerous blood condition called myelodysplastic syndrome (MDS) or a blood cancer called acute myeloid leukemia (AML). Symptoms of MDS and AML may include tiredness, fever, and easy bruising or bleeding. Call your healthcare provider if you develop these symptoms during treatment with NYVEPRIA.
Inflammation of the aorta (aortitis)
Inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) has been reported in patients who received pegfilgrastim products. Symptoms may include fever, abdominal pain, feeling tired, and back pain. Call your healthcare provider if you experience these symptoms.
The most common side effect of NYVEPRIA is pain in your bones and in your arms and legs.
These are not all the possible side effects of NYVEPRIA. Call your healthcare provider for medical advice about side effects. Your healthcare provider may recommend alternative treatments.
You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.